STAY CONNECTED! News & Updates during COVID-19 Learn More
Free Shipping on every subscription over $224.99
Unsurpassable 180-day satisfaction guarantee!
Mannatech Homepage


Help strengthen your gut barrier*

Item No.
Member $59.99
Retail $65.99
Add to Cart
Mission 5 Million® 13 servings of PhytoBlend™ powder are provided to a child in need with the purchase of this product. Learn More

Free Shipping

Every subscription of $224.99 or more!

Loyalty Points

Earn points towards FREE product!


Unsurpassable 180-day satisfaction guarantee!

Zero Risk Guarantee

Product Information


In order to create a strong, stable environment for beneficial bacteria to thrive, your intestinal lining requires an abundant supply of short-chain fatty acids (SCFA) known as butyrates. GI-Defense capsules, with an exclusive Glycobiome and Butyrate Support Blend, is specifically formulated to nourish and help strengthen the gut lining.* Containing powerful antioxidants and flavonoids, GI-Defense actually supports the body’s ability to produce its own arsenal of beneficial butyrates.* The result is a microbiome environment that is sound, balanced and better able to support healthy digestion and immunity. *

GI-Defense capsules are formulated to:

  • Help strengthen and support gut barrier function and integrity.*
  • Support healthy intestinal permeability and environment.*
  • Help purify the gut and balance beneficial bacteria.*
  • Support short chain fatty acid (SCFA) production, especially butyrate production.*
  • Contribute to the maintenance of the normal mucus function of the intestinal lining.*
  • Support healthy functioning of the immune and digestive systems.*
  • Help comfort feelings of gas and bloating.*


Orange extract (fruit of Citrus sinensis), Grapefruit extract (fruit of Citrus paradisi), Glucosamine HCl (vegetarian), Gum acacia, Arabinogalactan (from Larix spp. wood)Gum tragacanth, Aloe vera extract (inner leaf gel powder), Marshmallow root extract (Althaea officinalis), Grape seed extract (Vitis vinifera), Licorice root extract (Glycyrrhiza glabra), Cinnamon (dried bark of Cinnamomum cassia), Peppermint (leaf of Mentha piperita L.), Ginger (root of Zingiber officinale), Black pepper extract (fruit of Piper nigrum)Clove (flower of Syzygium aromaticum), Hydroxypropyl methylcellulose(vegetariancapsule), microcrystalline cellulose, stearic acid, silicon dioxide



GI-Defense™: Help Strengthen Your Gut Barrier


Supplement Facts

Product Information Sheet


Reviews collected from North America

Enjoy the Convenience of a Subscription

Setting your order to be delivered to your doorstep automatically is not only convenient but it means the benefits of the products you are taking will keep contributing toward your ongoing health and wellness!


Free Shipping

on every subscription
$224.99 or more!


Loyalty Points

you can use towards
FREE product!

Advance Your Wellness

Join the Mannatech family!


© 2024 Mannatech, Incorporated. All rights reserved.